Cortagen peptide (Ala-Glu-Asp-Pro) is a synthetic tetrapeptide originally derived from brain cortex extracts and studied for its bioregulatory, neuroprotective, and anti-aging properties.  It primarily acts at the epigenetic and gene expression level, influencing cellular repair, resilience, and function. 
Key Benefits:
Neuroprotection & Cognitive Support:
Cortagen enhances neuronal survival, reduces oxidative stress and neuroinflammation, and supports recovery after brain injury (e.g., stroke, traumatic brain injury).  It improves cognitive function, memory, mental clarity, and focus, particularly in age-related decline or stress-related cognitive fatigue. 
Nerve Regeneration & Repair:
Preclinical studies show Cortagen stimulates peripheral nerve regeneration, increasing nerve fiber growth rate and conduction velocity by 27–40% in injury models.  It promotes synaptic plasticity and helps restore neural connectivity.
Anti-Aging & Geroprotective Effects:
Cortagen helps restore youthful gene expression patterns by loosening condensed chromatin, reactivating genes silenced with age.  It reduces cellular senescence, supports ribosomal gene activity, and enhances antioxidant defenses—contributing to systemic anti-aging benefits. 
Cardiac & Immune System Modulation:
Research indicates Cortagen influences gene expression in the heart, potentially supporting cardiovascular health.  It also modulates immune responses by reducing autoimmune reactions and enhancing interleukin-2 expression, promoting balanced immune function. 
Stress & Hormonal Regulation:
By supporting adrenal function and regulating cortisol levels, Cortagen aids in stress management, energy metabolism, and maintaining hormonal balance. 
Skin Health (in specific formulations):
At Ageless Humans, Cortagen is used in topical treatments to boost collagen production, improve skin elasticity, reduce wrinkles, and enhance hydration and firmness. 
Summary:
Cortagen is a multi-system bioregulator with strong preclinical evidence for neuroprotection, nerve repair, cognitive enhancement, and anti-aging effects.  Its mechanism involves epigenetic regulation of gene expression, making it unique among nootropics.  While human clinical data are limited, it is used in research and clinical settings—especially in Russia—for neurological recovery and longevity support.