GHK Basic Peptide (glycyl-L-histidyl-L-lysine) is a naturally occurring tripeptide that plays a critical role in tissue repair, regeneration, and anti-aging processes. Its health benefits stem from its ability to modulate multiple cellular pathways and influence gene expression, particularly as levels decline with age.
Tissue Regeneration & Wound Healing: GHK basic promotes healing in skin, hair follicles, bone, gastrointestinal lining, and liver by stimulating collagen and glycosaminoglycan synthesis, enhancing angiogenesis (new blood vessel formation), and attracting immune and endothelial cells to injury sites.
Anti-Aging Effects: It reverses age-related decline by improving skin firmness, elasticity, and thickness, reducing fine lines and wrinkles, and restoring the skin’s protective barrier. Clinical studies show it outperforms vitamin C and retinoic acid in photoaged skin.
Gene Regulation & Cellular Health: GHK basic can up- and downregulate at least 4,000 human genes, effectively "resetting" pathological gene expression to a healthier state. It activates DNA repair, antioxidant systems, and the ubiquitin-proteasome system, while suppressing pro-inflammatory and cancer-promoting genes.
Neuroprotective & Cognitive Support: Research suggests it may help reverse age-related cognitive impairment by targeting anti-inflammatory and epigenetic pathways, with potential benefits for neurodegeneration and nervous system health.
Anti-Inflammatory & Antioxidant Activity: It reduces oxidative stress and inflammation, protects against UV damage, and supports stem cell function and cellular vitality.
Safety & Bioavailability: GHK basic is non-toxic, nontoxic at low nanomolar concentrations, and has been safely used in skincare and clinical studies for decades.
Its natural role as a signaling molecule released after tissue injury makes it a powerful modulator of regenerative biology, with applications in anti-aging, dermatology, and systemic tissue repair.

