Humanin peptide provides several key benefits due to its cytoprotective, anti-apoptotic, and antioxidant properties. It plays a crucial role in protecting cells from stress, oxidative damage, and programmed cell death, particularly in neurodegenerative conditions such as Alzheimer’s disease, Parkinson’s disease, and Huntington’s disease.
 Humanin exerts neuroprotective effects by interacting with specific receptors like the trimeric complex of gp130, WSX1, and CNTFR, as well as the formyl peptide receptor 2 (FPR2), which helps block amyloid-beta toxicity and reduce neuronal loss.
It supports metabolic health by enhancing insulin sensitivity and glucose uptake, which may help prevent insulin resistance and type 2 diabetes.
 Humanin stimulates insulin secretion and improves glucose regulation, contributing to better metabolic homeostasis.
 It also protects pancreatic β-cells, which are critical for insulin production, thereby supporting long-term metabolic function.
Humanin contributes to cardiovascular health by maintaining cardiac mitochondrial function and bioenergetics, which helps prevent ischemic injury and supports heart function under stress.
 It reduces inflammation by downregulating pro-inflammatory cytokines such as TNF-α and IL-6, and it helps maintain redox balance in mitochondria by restoring glutathione levels and reducing reactive oxygen species (ROS).
Furthermore, humanin is linked to longevity and healthspan. Higher levels of circulating humanin are observed in centenarians and long-lived individuals, and its overexpression has been associated with increased lifespan in model organisms.
 It helps preserve mitochondrial integrity, supports telomere stability, and counteracts age-related mitochondrial dysfunction, a key driver of aging and chronic disease.
Humanin also shows promise in protecting retinal pigment epithelial cells, suggesting potential benefits in age-related macular degeneration.
 Its ability to stabilize mitochondrial membrane potential and promote mitobiogenesis enhances cellular energy production and resilience.
 While not a performance-enhancing peptide, it supports long-term cellular recovery and resilience, making it valuable for anti-aging and systemic health protocols.
Despite its potential, humanin is still classified as a research peptide, not approved for human use by the FDA, and is prohibited in competitive sports under WADA’s S0 category.
 Its therapeutic applications remain under investigation, with clinical trials needed to confirm efficacy in humans.