Livagen peptide (Lys-Glu-Asp-Ala) is a bioregulatory tetrapeptide with multifaceted benefits primarily centered on cellular rejuvenation, immune support, and organ function optimization.  Its key benefits include:
Cellular Rejuvenation & Anti-Aging: Livagen promotes chromatin decondensation, reactivating silenced genes and restoring youthful gene expression.  This epigenetic reset enhances ribosomal gene activity, boosts protein synthesis in aging cells (evident in hepatocytes), and improves genomic stability, contributing to slowed biological aging and increased cellular resilience. 
Immune System Support: As a thymus-derived peptide, Livagen activates lymphocytes, enhances immune response, and supports T-cell production, leading to improved immune function, reduced inflammation, and better defense against infections and age-related immune decline. 
Liver Health & Metabolism: Livagen enhances liver function by supporting detoxification, bile production, fat metabolism, and cholesterol regulation.  It aids in tissue regeneration and improves metabolic efficiency, particularly in aged liver cells. 
Gastrointestinal Protection: It supports gut health by strengthening the mucosal barrier, modulating nitric oxide and prostaglandin levels, and increasing vagal nerve signaling—potentially beneficial for conditions like irritable bowel disease (IBD) and infectious diarrhea.
Stress & Pain Regulation: Livagen inhibits enkephalin-degrading enzymes in human serum (IC50 = 20 µM), increasing endogenous opioid levels.  This action enhances the body’s natural stress tolerance and may support pain control and neurological balance without directly binding to opioid receptors. 
Additional Benefits: Research suggests potential in retinal protection, cardiovascular health, neurological support, and cancer prevention through enhanced DNA repair and reduced oxidative stress.
Note: Livagen is primarily used in research and clinical settings. It is not FDA-approved for treating diseases.