Melanotan 1 (MT1) is a synthetic peptide that mimics alpha-melanocyte stimulating hormone (α-MSH), primarily acting on the melanocortin 1 receptor (MC1R) to stimulate melanin production in the skin.  Its key health and therapeutic benefits include:
Enhanced Skin Pigmentation and Sun Protection: MT1 increases melanin synthesis, leading to a natural tan without UV exposure. This provides a protective barrier against UV radiation, reducing the risk of sunburn, photoaging, and UV-induced skin damage. 
Treatment of Photosensitivity Disorders: Approved under the brand name Scenesse, MT1 is used to treat erythropoietic protoporphyria (EPP), a rare genetic condition causing extreme sensitivity to sunlight.  It significantly increases pain-free sun exposure and improves quality of life. 
Potential Therapy for Vitiligo: By promoting melanin production, MT1 may support repigmentation in areas affected by vitiligo, though research is ongoing. 
Neuroprotective and Cognitive Benefits: Preclinical studies suggest MT1 may enhance synaptic plasticity, reduce neuroinflammation, and protect brain cells from oxidative stress, indicating potential benefits for cognitive function and neurodegenerative conditions like Parkinson’s and stroke. 
Anti-inflammatory and Tissue-Protective Effects: MT1 has shown potential in reducing inflammation and supporting tissue resilience, with possible anti-fibrotic actions in inflamed tissues. 
Appetite and Metabolic Regulation: Research in animal models suggests MT1 may influence appetite regulation and metabolism, though findings remain preliminary. 
Improved Skin Resilience and Repair: MT1 supports natural skin defense mechanisms, with research exploring its role in skin barrier function, oxidative stress reduction, and recovery from damage. 
Important Note: Melanotan 1 is not FDA-approved for general use and is primarily available as a research peptide.  Its use outside clinical settings carries risks, including nausea, flushing, darkened moles, and unknown long-term safety. Always consult a healthcare professional before use.