PT-141, also known as Bremelanotide, is a synthetic peptide that provides benefits for sexual dysfunction by targeting the central nervous system rather than relying on vascular or hormonal mechanisms. It is FDA-approved under the name Vyleesi® for treating hypoactive sexual desire disorder (HSDD) in premenopausal women, with clinical evidence showing significant improvements in sexual desire, arousal, and satisfaction.
 For men, while not FDA-approved, PT-141 is used off-label to address erectile dysfunction, particularly in cases where traditional PDE-5 inhibitors like Viagra are ineffective, due to its ability to enhance both libido and erectile response through brain-based mechanisms.
Enhanced sexual desire and arousal: PT-141 stimulates melanocortin receptors (MC3R and MC4R) in the brain’s hypothalamus and arcuate nucleus, which are linked to sexual motivation and arousal, leading to increased desire and readiness for intimacy.
Non-hormonal treatment option: Unlike hormone-based therapies, PT-141 works independently of hormonal levels, making it suitable for individuals seeking to avoid hormonal interventions, especially women experiencing low libido due to menopause or psychological factors.
Dual mechanism of action: It triggers the release of nitric oxide in the brain, which relaxes penile muscles and increases blood flow, while also boosting dopamine signaling to enhance psychological arousal and motivation.
Improved sexual satisfaction and performance: Users report heightened sexual pleasure, better sexual performance, and more fulfilling intimate experiences, with effects typically beginning within 30–60 minutes of administration.
Potential for combination therapy: PT-141 can be used alongside PDE-5 inhibitors to address both desire and physical performance, offering a dual-pathway approach for comprehensive sexual health support.
Psychological and emotional benefits: By reactivating brain pathways involved in emotional response and intimacy, PT-141 may help reduce anxiety around sex and improve overall mood and connection with partners.