Sermorelin Acetate is a synthetic peptide that stimulates the body’s natural production of growth hormone (GH) by mimicking the action of growth hormone-releasing hormone (GHRH), offering a physiologic approach to hormone replacement therapy.
 It is used clinically to address age-related hormone decline, with benefits including improved energy, muscle mass, fat loss, and overall well-being.
Enhanced Growth Hormone and IGF-1 Production: Sermorelin increases natural GH release and insulin-like growth factor 1 (IGF-1) levels, with studies showing IGF-1 levels in older adults approaching those of younger individuals.
Improved Body Composition: Users may experience increased lean muscle mass and reduced body fat, particularly visceral fat, with one study noting a 1.26 kg increase in lean mass after 16 weeks of treatment.
Better Sleep Quality: Sermorelin aligns with natural GH release patterns, which peak during early-night slow-wave sleep, potentially improving deep, restorative sleep.
Cognitive and Emotional Benefits: Improved mental focus, memory, mood, and reduced feelings of “mental fog” are commonly reported, along with increased libido and emotional well-being.
Skin, Hair, and Bone Health: Enhanced skin elasticity, reduced wrinkles, improved hair and nail health, and increased bone density have been observed.
Metabolic and Cardiovascular Support: Sermorelin may improve insulin sensitivity, support fat metabolism, and contribute to better cardiovascular health, including potential reductions in systolic blood pressure.
Recovery and Performance: It supports faster recovery, improved muscle endurance, and enhanced athletic performance when combined with proper training and nutrition.
Safety and Natural Regulation: Unlike exogenous growth hormone, sermorelin works with the body’s natural negative feedback system, reducing the risk of hormonal imbalances and side effects.
Treatment is typically administered via subcutaneous injection before bedtime, with protocols lasting 3 to 6 months under clinical supervision.
 As of January 2026, ongoing research continues to explore its role in longevity and fitness, including pairing with NAD+ for enhanced cellular support.