TB-500 (Thymosin Beta-4) is a synthetic peptide derived from the naturally occurring protein thymosin beta-4, found in nearly all human cells. It plays a key role in tissue repair, cell migration, and inflammation reduction.
Its primary mechanism involves regulating actin, a protein essential for cell structure and movement. This promotes:
Accelerated healing of muscle, tendon, and ligament injuries
Angiogenesis (formation of new blood vessels)
Reduction of inflammation and fibrosis
Increased collagen deposition and stem cell differentiation
Used off-label and in research, TB-500 is not FDA-approved for human use and is banned by WADA in sports. It is typically administered via subcutaneous injection.
Common side effects are mild and include injection site reactions, fatigue, or headaches. Due to limited human studies, long-term risks—such as potential cancer promotion—remain theoretical but unconfirmed.