Vasoactive Intestinal Peptide (VIP) is a 28-amino-acid neuropeptide with wide-ranging physiological roles, offering multiple health benefits across several systems:
Immune Modulation & Anti-Inflammatory Effects: VIP acts as a potent anti-inflammatory and immune modulator, reducing pro-inflammatory cytokines (e.g., IL-1, IL-6, TNF-α) while increasing anti-inflammatory ones (e.g., IL-4, IL-10).  It helps balance Th1/Th2 responses, making it beneficial for autoimmune diseases, chronic inflammation, and Chronic Inflammatory Response Syndrome (CIRS) due to mold exposure. 
Respiratory Health: VIP functions as a bronchodilator and anti-inflammatory agent in the lungs, improving airflow and reducing bronchoconstriction.  It supports asthma, COPD, and pulmonary hypertension by relaxing airway smooth muscles, reducing inflammation, and promoting surfactant production. 
Gastrointestinal Health: VIP regulates gut motility, reduces intestinal inflammation, and supports gut barrier integrity.  It enhances secretion of digestive fluids, promotes mucus production, and helps manage conditions like irritable bowel syndrome (IBS), inflammatory bowel disease (IBD), and bloating. 
Cardiovascular Support: VIP is a powerful vasodilator, improving blood flow and reducing vascular resistance.  It lowers blood pressure, enhances coronary circulation, and has cardioprotective effects, supporting heart function and reducing strain on the cardiovascular system. 
Neurological & Cognitive Benefits: VIP supports brain health by reducing neuroinflammation, promoting neuroplasticity, and protecting against oxidative stress.  It may help with brain fog, cognitive fatigue, Alzheimer’s, and Parkinson’s disease. 
Joint & Bone Health: VIP helps protect cartilage, inhibit joint destruction, and reduce inflammation in osteoarthritis (OA) and rheumatoid arthritis by modulating immune responses and preventing cartilage degradation. 
Circadian Rhythm Regulation: VIP plays a key role in synchronizing the body’s internal clock (suprachiasmatic nucleus), improving sleep quality, energy levels, and overall circadian health. 
Metabolic & Hormonal Balance: VIP influences hormone secretion (e.g., insulin, glucagon, prolactin), supports glucose metabolism, and may aid in managing type 2 diabetes and hormonal imbalances. 
Note: VIP is used in peptide therapy (e.g., nasal spray or injectable) for conditions like mold toxicity, chronic fatigue, and autoimmune disorders.  However, it is contraindicated in active cancer, pregnancy, and breastfeeding. Benefits typically appear within 1–12 weeks, with full effects seen after 3 months of consistent use.